Fifty Years of Fibrinogen Structure and Function

Authors: Neerman-Arbez, M; Casini, A

Affiliations: Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Division of Angiology and Hemostasis, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Publication: Seminars in thrombosis and hemostasis. 2023.

Abstract: Reissuing historical scientific papers from the Seminars in Thrombosis and Hemostasis “vault” or treasure trove to celebrate 50 years of publishing is a fantastic idea, bringing important original studies or reviews such as “The Molecular Structure of Fibrinogen” by Murano back into the light for new generations of scientists to discover them or more senior colleagues to rediscover. It is very appropriate that the first article published in Seminars in Thrombosis and Hemostasis focused on fibrinogen, the final substrate of the coagulation cascade and without much contest (but maybe a little bias!) the molecule which is the most central for maintaining a healthy hemostatic balance between clot formation and clot lysis. Indeed, abnormal fibrinogen levels or abnormal fibrin(ogen) structures can perturb the balance, leading to bleeding manifestations, thrombosis, or both.