The Choice between Intravenous and Subcutaneous Immunoglobulins: Aspects for Consideration

Authors: Achenbach, C von; Hernandez, GH; Gunten, S von

Affiliations: Univ Bern, Inst Pharmacol, Bern, Switzerland, CSL Behring AG, Bern, Switzerland, Univ Bern, Bern Ctr Precis Med BCPM, Bern, Switzerland

Publication: Pharmacology; 2022

Abstract: BACKGROUND: Intravenous immunoglobulin and subcutaneous immunoglobulin preparations are used to treat primary and secondary immunodeficiencies, as well as autoimmune and inflammatory conditions. SUMMARY: For certain indications, only defined formulations or routes of administration are approved by health authorities. However, for other diseases, there are more options, and treatment decisions may be based on different aspects, such as patient conditions and preferences, pharmacokinetics, or pharmacoeconomic considerations. KEY MESSAGES: Understanding the two different treatment modalities may support the decision-making for the optimal therapeutic option for individual patients. This review summarizes the latest insights into the direct and indirect comparison between the two types of products.