Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

Authors: Scott, D. W. and Pratt, K. P.

Front Immunol January 2020,

Affiliations: Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Abstract: Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.