Factor VII Activating Protease (FSAP) and Its Importance in Hemostasis-Part I: FSAP Structure, Synthesis and Activity Regulation: A Narrative Review

Authors: Kwiatkowska, I; Zekanowska, E; Lattanzi, S; Alexandre, AM; Kister-Kowalska, A; Slomka, A

Affiliations: Nicolaus Copernicus Univ Torun, Dept Pathophysiol, Ludw Rydygier Coll Medicum, PL-85094 Bydgoszcz, Poland. Marche Polytech Univ, Dept Expt & Clin Med, Neurol Clin, I-60121 Ancona, Italy. Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncol, UOC Radiol & Neuroradiol, I-00168 Rome, Italy. Jan Biziel Univ Hosp 2, Dept Pathomorphol Placentol & Clin Hematopathol, PL-85168 Bydgoszcz, Poland.

Publication: International journal of molecular sciences; 2023; 24

Abstract: Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago. Since then, many research groups have described the biological properties of this protease and its role in hemostasis and other processes in humans and other animals. With the progress of knowledge about the structure of FSAP, several of its relationships with other proteins or chemical compounds that may modulate its activity have been explained. These mutual axes are described in the present narrative review. The first part of our series of manuscripts on FSAP describes the structure of this protein and the processes leading to the enhancement and inhibition of its activities. The following parts, II and III, concern the role of FSAP in hemostasis and in the pathophysiology of human diseases, with particular emphasis on cardiovascular diseases.