Challenges in Ageing Persons with Haemophilia

Authors: Makris, M; Lassila, R; Kennedy, M

Affiliations: School of Medicine and Population Health, University of Sheffield, Sheffield, UK. Helsinki University Hospital, Department of Haematology, Coagulation Disorders Unit, Comprehensive Cancer Centre, Faculty of Medicine, Research Program Unit in Systems Oncology, University of Helsinki, Helsinki, Finland. Discipline of Physiotherapy, School of Medicine, University of Dublin, Trinity College Dublin, Dublin, Ireland.

Publication: Haemophilia. 2024

Abstract: As treatments for individuals with inherited bleeding disorders improve, life expectancy increases and is approaching that of the normal population. Concomitant with this we are now seeing the problems of ageing in the bleeding disorder population. Although the clear-cut association between low clotting factor levels and risk of bleeding is well recognized, a relationship between high levels, some non-factor therapies and thrombotic risk also exists. The management of thrombosis in persons with inherited bleeding disorders is complex but manageable with modern treatments and collaboration in decision making between health care professionals and patients. Despite the improvements in treatment and reduction in bleeding, mostly musculoskeletal pain continues to be a major issue with advancing age. The management of pain amongst older people with haemophilia who may have multiple comorbidities should involve a person-centered, holistic, multi-disciplinary approach to support and optimize long-term physical functioning and overall quality of life.