BMI is an important determinant of VWF and FVIII levels and bleeding phenotype in patients with von Willebrand disease

Authors: Ferdows Atiq, Karin Fijnvandraat, Karin P M van Galen, Britta A P Laros-van Gorkom, Karina Meijer, Joke de Meris, Michiel Coppens, Eveline P Mauser-Bunschoten, Marjon H Cnossen, Johanna G van der Bom, Jeroen Eikenboom, Frank W G Leebeek, for the WiN study group

Published: doi: 10.1002/ajh.25499

Abstract: To conclude, higher BMI is associated with higher VWF and FVIII levels in patients with type 1 and type 2 VWD, compared to normal weight VWD patients. However, higher BMI does not seem to protect against bleeding. Despite these higher VWF and FVIII levels, VWD patients with overweight and obesity had more bleeding symptoms in the year prior to inclusion than patients with normal weight.